Routes of
administration IV Legal status Investigational PubChem CID 127894 Molar mass 279.338 g/mol Pubchem 127894 ChemSpider ID 113428 | ATC code none CAS Number 150131-78-5 IUPHAR/BPS 4245 Route Intravenous therapy ChEMBL ID 14935 IUPHAR/BP 4245 | |
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What does tezampanel mean
Tezampanel (INN, USAN) (code names LY-293,558, NGX-424) is a drug originally developed by Eli Lilly which acts as a competitive antagonist of the AMPA and kainate subtypes of the ionotropic glutamate receptor family, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant properties, the former of which may, at least in part, occur via blockade of calcium uptake into neurons.
Contents
Tezampanel has a range of effects which may be useful for medicinal purposes, as well as its applications in scientific research. It suppresses both the withdrawal symptoms from morphine and other opioids, and the development of tolerance, as well as having antihyperalgesic and analgesic effects in its own right. It also has anxiolytic effects in animal studies and has been suggested as a candidate for the treatment of anxiety in humans.