Species Human Entrez 29110 | Human Mouse Ensembl ENSG00000183735 | |
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Aliases TBK1, Tbk1, 1200008B05Rik, AI462036, AW048562, NAK, T2K, FTDALS4, TANK binding kinase 1 External IDs MGI: 1929658 HomoloGene: 22742 GeneCards: TBK1 | ||
Serine/threonine-protein kinase TBK1 is an enzyme that in humans is encoded by the TBK1 gene.
Contents
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
Interactions
TANK-binding kinase 1 has been shown to interact with:
Transcriptional factors activated upon TBK1 activation include IRF3, IRF7 and ZEB1.
Clinical significance
Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer.