Sena was born in Dearborn, Michigan. An Edsel Ford High School graduate, she has a Bachelor of Arts degree in communications from Michigan State University.
Sena started her national television career on E! Entertainment Television. While at E!, she was a fill-in anchor and correspondent for E! News Daily. Sena created, hosted and oversaw production on the reality-lifestyle celebrity series Out to Lunch and regularly appeared on the red carpet, hosting live coverage of events including the Emmy Awards and the Academy Awards. In 2005, Sena received an Emmy nomination for hosting the show, Celebrity Homes.
Sena was considered a front runner in the search for Kathie Lee Gifford's replacement on Live with Regis, co-hosting with Regis Philbin for four shows. Both the New York Post and Entertainment Weekly cited Sena as the likely winner of the position.
From 2004 to 2006 Sena worked at Fort Worth-based KTVT-TV (CBS11). From 2006 to 2008, worked as an anchor at the Fox News Channel. She anchored the network's primetime news updates and handled breaking news in the overnight hours. While at Fox News, Sena made appearances on Red Eye w/ Greg Gutfeld and Fox and Friends, filling in as news anchor.
In 2010-2011, Sena was critically acclaimed for her performance as Brooke Alvarez on the IFC series Onion News Network, a satire of television journalism. Concurrently, she also hosted the online lifestyle reality show, "The Invested Life."
Sena is also an entrepreneur. Her media training business, Sena Series Media Coaching and Teleprompter Training Techniques, is responsible for training many of today's top broadcast television talent.
In 2014, Sena appeared in several popular episodic television series, including Castle, How to Get Away With Murder, Sullivan & Son, and the Amazon pilot, Down Dog. She co-starred and produced the comedic horror film, Killer Party and starred in an independent movie.
She continues to work as a successful direct response host, appearing as a correspondent and host in various infomercials.