Formula C25H40N7O19P3S | ||
Amino acid oxidation pathways part 7 of 10 amino acids degraded to succinyl coa
Succinyl-Coenzyme A, abbreviated as Succinyl-CoA (/ˌsʌksᵻnəlˌkoʊˈeɪ/) or SucCoA, is a combination of succinic acid and coenzyme A.
Contents
- Amino acid oxidation pathways part 7 of 10 amino acids degraded to succinyl coa
- 1631 succinyl coa synthetase or succinate dehydrogenase
- Fate
- Formation
- Interactive pathway map
- References
1631 succinyl coa synthetase or succinate dehydrogenase
Fate
It is converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase (succinate thiokinase).
Another fate of succinyl-CoA is porphyrin synthesis, where succinyl-CoA and glycine are combined by ALA synthase to form δ-aminolevulinic acid (dALA).
Formation
Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by the enzyme methylmalonyl-CoA mutase. This reaction, which requires vitamin B12 as a cofactor, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
