Harman Patil (Editor)

Sodium–hydrogen antiporter 3

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Species
  
Human

Entrez
  
6550

Human
  
Mouse

Ensembl
  
n/a

Sodium–hydrogen antiporter 3

Aliases
  
SLC9A3, NHE3, NHE-3, Sodium–hydrogen antiporter 3, DIAR8, solute carrier family 9 member A3

External IDs
  
MGI: 105064 HomoloGene: 55804 GeneCards: SLC9A3

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.

Contents

SLC9A3 is a sodium–hydrogen antiporter. It is found in the tubulus proximal of the nephron of the kidney and in the apical membrane of enterocytes of the intestine. It is primarily responsible for maintaining the balance of sodium.

Regulation

Protein kinase C stimulates NHE3, while protein kinase A inhibits it.

There is a specific protein functioning as an NHE3 regulator, Sodium-hydrogen antiporter 3 regulator 1.

Inhibitors

  • Tenapanor

    • Stimulators

  • Insulin stimulates NHE3 and thereby proximal tubule sodium absorption.

    • Interactions

    Sodium–hydrogen antiporter 3 has been shown to interact with CHP.

    References

    Sodium–hydrogen antiporter 3 Wikipedia
    (Text) CC BY-SA