Entrez 6550 | Ensembl n/a | |
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Aliases SLC9A3, NHE3, NHE-3, Sodium–hydrogen antiporter 3, DIAR8, solute carrier family 9 member A3 External IDs MGI: 105064 HomoloGene: 55804 GeneCards: SLC9A3 | ||
Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a protein that in humans is encoded by the SLC9A3 gene.
Contents
SLC9A3 is a sodium–hydrogen antiporter. It is found in the tubulus proximal of the nephron of the kidney and in the apical membrane of enterocytes of the intestine. It is primarily responsible for maintaining the balance of sodium.
Regulation
Protein kinase C stimulates NHE3, while protein kinase A inhibits it.
There is a specific protein functioning as an NHE3 regulator, Sodium-hydrogen antiporter 3 regulator 1.
Inhibitors
Stimulators
Interactions
Sodium–hydrogen antiporter 3 has been shown to interact with CHP.
References
Sodium–hydrogen antiporter 3 Wikipedia(Text) CC BY-SA