Morris is originally from Marin County, California - the younger of two boys - and attended Novato High School. After graduating, not knowing what he wanted to do, he went back and forth between traveling and community college. This included a stint at UC Santa Cruz and a six-month bicycling trip across the country, from San Francisco to Florida.
Morris has worked numerous odd jobs including working with developmentally disabled people at group homes, teaching kids and a health food / yoga store in NYC.
Morris started a career in comedy after moving to New York City in 1997, performing at the Upright Citizens Brigade Theatre (UCB) as an improviser and sketch comedian.
He later moved to LA and became the first Artistic Director of the theater's Los Angeles division for many years and was a member of the four-man sketch group "The Naked Babies" with comedians Rob Corddry, Brian Huskey, and John Ross Bowie. After stepping down from that position, he started out as the first staff writer hired by Funny or Die.
He currently writes and appears with a recurring role on Corddry's Adult Swim series Childrens Hospital. Morris also recurred as Scotty on the ABC comedy series Happy Endings and as Danny on the NBC comedy series Go On. Other programs Morris appeared in regularly included Late Night with Conan O'Brien, the HBO sketch series Funny or Die Presents, and the MTV prank show Damage Control.
Morris has also made numerous guest appearances on comedy programs such as Curb Your Enthusiasm, Parks and Recreation, The League, Reno 911!, Crossballs, It's Always Sunny In Philadelphia, Maron, How I Met Your Mother, Broad City, Big Lake, Human Giant, and Nick Swardson's Pretend Time. He has appeared in films such as The Dictator, Step Brothers, Blackballed: The Bobby Dukes Story, and I Love You, Man. In 2012, Morris starred in the comedic web series First Dates with Toby Harris, produced by Yahoo! and Funny or Die.
Morris is a frequent writer and director for the humor website Funny Or Die. He is also known for his regular appearances on the Comedy Bang! Bang! podcast and television series, most often playing Bob Ducca, the hypochondriac ex-stepfather of host Scott Aukerman. Morris also hosted his own podcast on the Earwolf podcasting network, Affirmation Nation with Bob Ducca, which debuted in 2011, ran for 144 episodes, and stopped airing on February 29, 2012. As of October 1, 2014, Affirmation Nation released its first of a new run of episodes. However, on May 6, 2015 he published the last episode of Affirmation Nation. He wrote for the Comedy Central sketch series Kroll Show. Morris has also costarred in the Hulu series The Hotwives of Orlando.