Girish Mahajan (Editor)

STAT6

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Species
  
Human

Entrez
  
6778

Human
  
Mouse

Ensembl
  
ENSG00000166888

STAT6

Aliases
  
STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6

External IDs
  
OMIM: 601512 MGI: 103034 HomoloGene: 2373 GeneCards: STAT6

Signal transducer and activator of transcription 6 (STAT6) is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.

Contents

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.

Interactions

STAT6 has been shown to interact with:

  • CREB-binding protein,
  • EP300,
  • IRF4,
  • NFKB1,
  • Nuclear receptor coactivator 1, and
  • SND1.
  • Pathology

  • Gene fusion
  • Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.
  • Amplification
  • STAT6 is amplified in a subset of dedifferentiated liposarcoma.
  • References

    STAT6 Wikipedia