Species Human Entrez 8648 | Human Mouse Ensembl ENSG00000084676 | |
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Aliases NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74, nuclear receptor coactivator 1 External IDs MGI: 1276523 HomoloGene: 7859 GeneCards: NCOA1 | ||
The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.
NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).
Interactions
Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:
References
Nuclear receptor coactivator 1 Wikipedia(Text) CC BY-SA