Entrez 3662 | Ensembl ENSG00000137265 | |
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Aliases IRF4, LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4 External IDs MGI: 1096873 HomoloGene: 1842 GeneCards: IRF4 | ||
Interferon regulatory factor 4 also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23.
Contents
The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3).
Clinical significance
In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. A variant has been implicated in greying of hair.
Interactions
IRF4 has been shown to interact with:
References
IRF4 Wikipedia(Text) CC BY-SA