Species Human Entrez 8243 | Human Mouse Ensembl ENSG00000072501 | |
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Aliases SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A External IDs MGI: 1344345 HomoloGene: 4597 GeneCards: SMC1A | ||
Structural maintenance of chromosomes protein 1A is a protein that in humans is encoded by the SMC1A gene.
Contents
Function
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
Interactions
SMC1A has been shown to interact with SMC3 and Ataxia telangiectasia mutated.