Entrez 8467 | Ensembl ENSG00000153147 | |
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Aliases SMARCA5, ISWI, SNF2H, WCRF135, hISWI, hSNF2H, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 External IDs MGI: 1935129 HomoloGene: 55764 GeneCards: SMARCA5 | ||
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.
Contents
Function
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
Interactions
SMARCA5 has been shown to interact with RAD21, Histone deacetylase 2, POLE3, SATB1 and BAZ1A.