Kalpana Kalpana (Editor)

BAZ1A

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Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.

Contents

Structure

The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:

  • N-terminus – PHD finger (C4HC3 zinc finger)
  • WAKZ motif
  • LH (leucine-rich helical domain) motif
  • C-terminus – bromodomain

    • Function

    BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.

    The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent. Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.

    Interactions

    BAZ1A has been shown to interact with SMARCA5 and SATB1.

    References

    BAZ1A Wikipedia
    (Text) CC BY-SA