Tripti Joshi (Editor)

Rudolf Jaenisch

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Citizenship
  
Role
  
Professor

Name
  
Rudolf Jaenisch

Academic advisors
  
Arnold Levine


Rudolf Jaenisch Whitehead Institute News 2014 Whitehead39s Jaenisch

Born
  
22 April 1942 (age 82) Wolfelsgrund, Germany (
1942-04-22
)

Institutions
  
Max Planck Institute for BiochemistryPrinceton UniversityFox Chase Cancer CenterSalk InstituteHeinrich Pette InstituteUniversity of HamburgWhitehead Institute for Biomedical ResearchMassachusetts Institute of Technology

Alma mater
  
University of Munich (M.D., 1967)

Known for
  
Epigenetic mechanisms of gene regulationTherapeutic cloningEmbryonic stem cell research

Notable awards
  
Boehringer Mannheim Molecular Bioanalytics Prize (1996)Gruber Prize in Genetics (2001)Robert Koch Prize (2002)Max Delbruck Medal (2006)Massry Prize from the Keck School of Medicine (2008)Wolf Prize in Medicine (2011)National Medal of Science (2011)

Education
  
Ludwig Maximilian University of Munich

Residence
  
Germany, United States of America

Awards
  
Wolf Prize in Medicine, Robert Koch Prize, Massry Prize, National Medal of Science for Biological Sciences

Fields
  
Similar People
  
Shinya Yamanaka, Kevin Eggan, James Thomson

Organizations founded
  
Fate Therapeutics

2010 Killian Lecture: Rudolph Jaenisch, "Making Stem-cell Therapy a Reality"


Rudolf Jaenisch (born 22 April 1942) is a Professor of Biology at MIT and a founding member of the Whitehead Institute for Biomedical Research. He is a pioneer of transgenic science, in which an animal’s genetic makeup is altered. Jaenisch has focused on creating genetically modified mice to study cancer and neurological diseases.

Contents

Rudolf Jaenisch pulsewimiteduwpcontentuploads201109jaenis

Genetic manipulation in stem cells rudolf jaenisch


Research

Rudolf Jaenisch Whitehead member biology professor Rudolf Jaenisch wins

Jaenisch’s first breakthrough occurred in 1974 when he and Beatrice Mintz showed that foreign DNA could be integrated into the DNA of early mouse embryos. They injected retrovirus DNA into early mouse embryos and showed that leukemia DNA sequences had integrated into the mouse genome and also to its offspring. These mice were the first transgenic mammals in history.

Rudolf Jaenisch US stem cell expert is hottest researcher Reuters

His current research focuses on the epigenetic regulation of gene expression, which has led to major advances in creating embryonic stem cells and “induced pluripotent stem" (IPS) cells, as well as their therapeutic applications. In 2007, Jaenisch’s laboratory was one of the first three laboratories world-wide to report reprogramming cells taken from a mouse's tail into IPS cells. Jaenisch has since shown therapeutic benefits of IPS cell-based treatment for sickle-cell anemia and Parkinson's disease in mice. Additional research focuses on the epigenetic mechanisms involved in cancer and brain development.

Jaenisch’s therapeutic cloning research deals exclusively with mice, but he is an advocate for using the same techniques with human cells in order to advance embryonic stem cell research. However, in 2001 Jaenisch made a public case against human reproductive cloning, testifying to a U.S. House of Representatives subcommittee and an editorial in Science magazine.

Career

Jaenisch received his doctorate in medicine from the University of Munich in 1967, preferring the laboratory to the clinic. He became a postdoc at the Max Planck Institute in Munich, studying bacteriophages. He left Germany in 1970 for research positions at Princeton University, Fox Chase Institute for Cancer Research and the Salk Institute. He returned to Germany in 1977 to become the head of the Department of Tumor Virology at the Heinrich Pette Institute at the University of Hamburg. He arrived at MIT in 1984. He participated in the 2005 science conference on human cloning at the United Nations and serves on the science advisory boards of the Genetics Policy Institute and Stemgent.

Awards and honors

  • 2001, inaugural Genetics Prize of the Gruber Foundation
  • 2002 Robert Koch Prize
  • 2003 Election as a member of U.S. National Academy of Sciences
  • 2006 Max Delbrück Medal
  • 2007 Vilcek Prize in Biomedical Science
  • 2009 Ernst Schering Prize
  • 2010 National Medal of Science
  • 2011 Wolf Prize in Medicine
  • 2013 Benjamin Franklin Medal in Life Science from the Franklin Institute
  • 2013 Passano Award
  • 2014 Otto Warburg Medal
  • 2015 March of Dimes Prize in Developmental Biology
  • References

    Rudolf Jaenisch Wikipedia


    Similar Topics