Gene COMT Region Exon 3 dbSNP 4680 | Chromosome 22 Ensembl Human SNPView | |
Name(s) Val158Met, Val108/158Met, G1947A | ||
In genetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the COMT gene that codes catechol-O-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158.
The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour.
The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the SzGene database shows no or very little effect.
Several personality genetics studies have examined the association of the polymorphism with personality traits.
References
Rs4680 Wikipedia(Text) CC BY-SA