Harman Patil (Editor)

Retinoic acid receptor alpha

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Entrez
  
5914

Human
  
Ensembl
  
ENSG00000131759

Retinoic acid receptor alpha

Aliases
  
RARA, NR1B1, RAR, retinoic acid receptor alpha

External IDs
  
MGI: 97856 HomoloGene: 20262 GeneCards: RARA

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor that in humans is encoded by the RARA gene.

Contents

Function

Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT (NCOR2), and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.

Clinical significance

Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene.

Interactions

Retinoic acid receptor alpha has been shown to interact with:

References

Retinoic acid receptor alpha Wikipedia


Similar Topics