Samiksha Jaiswal (Editor)

Prototheca wickerhamii

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Domain
  
Eukaryota

Phylum
  
Order
  
Scientific name
  
Prototheca wickerhamii

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Species

Prototheca wickerhamii Prototheca wickerhamii Wikipedia

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Prototheca, Prototheca zopfii, Helicosporidium, Trebouxiophyceae, Nephroselmis

Prototheca wickerhamii is a ubiquitous green alga that does not have chlorophyll. It is widely present in the environment and is a rare cause of infection in humans (protothecosis) and most commonly presents as nodules of the skin. Most cases reported have a suppressed immune system (from drugs or disease). Infection usually results by direct traumatic inoculation.

Contents

Prototheca wickerhamii Details Public Health Image Library PHIL

Identification

Prototheca wickerhamii httpsuploadwikimediaorgwikipediacommonsthu

Diagnosis can be made through culture of infected fluid in Sabouraud dextrose agar or by visualization of sporangia containing sporangiospores on tissue biopsy (using hematoxylin/eosin, GMS, or PAS histochemical stains). The organism incites a chronic granulomatous inflammation with infiltrate of histiocytes, lymphocytes, giant cells and occasional eosinophils. The organism has thick wall, internal septations, measures 3-11 µm in diameter. The sporangia have very small wedge-shaped endospores arranged radially and moulded (morula-like form).

Differential diagnosis: Protothecal sporangia may be confused with Coccidioides immitis, which are much larger

Antimicrobial therapy

Treatment is not standardized. Amphotericin B, itraconazole, posaconazole and voriconazole have all been tried.

Prototheca wickerhamii Pblaschkeaewebjpg

Prototheca wickerhamii Protothecosis Wikipedia

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Prototheca wickerhamii Prototheca Mycology Online

References

Prototheca wickerhamii Wikipedia


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