Philippa Marrack

Updated on Dec 25, 2023

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Doctoral advisor Alan Munro Spouse John Kappler		Role Biologist Name Philippa Marrack

Born 28 June 1945 (age 78) Ewell, England ( 1945-06-28 ) Alma mater Cambridge UniversityUniversity of California, San Diego Known for T cells, autoimmune disease Notable awards Louisa Gross Horwitz Prize (1995)Dickson Prize (1996) Education University of Cambridge, University of California, San Diego Awards Wolf Prize in Medicine, Louisa Gross Horwitz Prize Similar People John Kappler, Harald von Boehmer, Christine Petit, Carlotta Walls LaNier
Institutions National Jewish Health

Philippa Marrack - How Crucial is Competitiveness to a Scientific Career?

Philippa "Pippa" Marrack FRS (born 28 June 1945) is an English biologist, based in the United States, best known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome. She collaborates with her husband, John W. Kappler.

Philippa Marrack Philippa Marrack PhD HHMIorg

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Biography

Philippa Marrack Beyond Expectation The Scientist Magazine

Marrack was born in Ewell, England on 28 June 1945. She completed both undergraduate (1967) and PhD (1970) work at New Hall, Cambridge. During her PhD, she worked at the MRC Laboratory of Molecular Biology with Alan Munro, where she began to study the differences between T cells and B cells.

Philippa Marrack Philippa Marrack PhD FRS

She later did postdoctoral work with Richard Dutton at the University of California, San Diego.

Her first faculty position was with the University of Rochester, followed by National Jewish Health, Denver, Colorado and the University of Colorado.

Significant papers

J.W. Kappler, M. Roehm, P. Marrack, "T cell tolerance by clonal elimination in the thymus," Cell, v.49, n.2, pp. 273–80 (1987)

P. Marrack and J. Kappler, "The Staphylococcal Enterotoxins and Their Relatives," Science, v.248 (4956), pp. 705–11 (1990).

J.W. Kappler, U. Staerz, J. White, P.C. Marrack, "Self-Tolerance Eliminates T Cells Specific for MIS-Modified Products of the Major Histocompatibility Complex," Nature, 332 (6159): pp. 35–40 (1988).

J. White, et al. (P.C. Marrack), "The V(beta)-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletions in neonatal mice," Cell, v.56, n.1, pp. 27–35 (1989).