Suvarna Garge (Editor)

Neurotensin receptor

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Symbol
  
NTSR1

Entrez
  
4923

OMIM
  
162651

Alt. symbols
  
NTR

HUGO
  
8039

RefSeq
  
NM_002531

The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

Contents

Agonists

Peptide
  • Beta-lactotensin (NTS2)
  • JMV-449
  • Neurotensin
  • Neuromedin N (NTS1 selective)
  • PD-149,163 (NTS1 selective, reduced amide bond 8-13 fragment of neurotensin)
    • Non-peptide
  • Partial agonists derived from SR-48692

    • Antagonists

  • Levocabastine (NTS2 selective, also H1 histamine antagonist)
  • SR-48692 (NTS1 selective)
  • SR-142,948 (unselective, CAS# 184162-64-9)

    • Biophysical Investigation

    Unusually for GPCRs, NTS1 can be expressed in an active form in the bacteria E. coli. It can be purified and analysed in vitro and has been analysed by a number of biophysical techniques such as surface plasmon resonance, FRET and cryo-electron microscopy.

    References

    Neurotensin receptor Wikipedia
    (Text) CC BY-SA