Kalpana Kalpana (Editor)

Neuronal calcium sensor

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Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.

Members of NCS family

  • Highly evolutionarily conserved
  • NCS1 (Frequenin)
  • VILIP-1 (Visinin-like-protein-1)
  • HPCAL4 (Visinin-like-protein-2)
  • HPCAL1 (Visinin-like-protein-3)
  • hippocalcin
  • neurocalcin
  • recoverin
  • Guanylate cyclase activator proteins (GCAPs)
  • Potassium Channel interacting proteins (KChIPs 1-4), including:

    • KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4

    References

    Neuronal calcium sensor Wikipedia
    (Text) CC BY-SA