Supriya Ghosh (Editor)

Hippocalcin

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Species
  
Human

Entrez
  
3208

Human
  
Mouse

Ensembl
  
ENSG00000121905

Aliases
  
HPCA, BDR2, DYT2, hippocalcin

External IDs
  
OMIM: 142622 MGI: 1336200 HomoloGene: 55634 GeneCards: HPCA

Hippocalcin is a protein that in humans is encoded by the HPCA gene.

Contents

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.

Processes

Hippocalcin takes part in the following processes:

  • Activation of PLD1 and PLD2 expression
  • Inhibition of apoptosis
  • MAP kinase signalling
  • Involved in long term depression in hippocampal neuron
  • Required for normal spatial learning

    • Interactions

    Hippocalcin interacts with following proteins:

  • Neuronal apoptosis inhibitory protein (NAIP)
  • Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
  • The b2 adaptin of the AP2 complex
  • Calcium-dependent activator protein for secretion (CADPS)

    • References

    Hippocalcin Wikipedia
    (Text) CC BY-SA