Hippocalcin

Updated on Sep 30, 2024

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Species Human Entrez 3208		Human Mouse Ensembl ENSG00000121905
Aliases HPCA, BDR2, DYT2, hippocalcin External IDs OMIM: 142622 MGI: 1336200 HomoloGene: 55634 GeneCards: HPCA

Hippocalcin is a protein that in humans is encoded by the HPCA gene.

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.

Processes

Hippocalcin takes part in the following processes:

Activation of PLD1 and PLD2 expression

Inhibition of apoptosis

MAP kinase signalling

Involved in long term depression in hippocampal neuron

Required for normal spatial learning

Hippocalcin interacts with following proteins:

Neuronal apoptosis inhibitory protein (NAIP)

Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2

The b2 adaptin of the AP2 complex

Calcium-dependent activator protein for secretion (CADPS)

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