Species Human Entrez 30820 | Human Mouse Ensembl ENSG00000182132 | |
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Aliases KCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1 External IDs MGI: 1917607 HomoloGene: 22824 GeneCards: KCNIP1 | ||
Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.
Function
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.
References
KCNIP1 Wikipedia(Text) CC BY-SA