In 1988 she took part in the Sanremo Music Festival in the New comers category with Sogno. It didn't happen, however it was noticed by the melodic songwriter Amedeo Minghi, who wrote the song Canzoni for her in the following year. Mietta won the New comers category and the critics award Mia Martini. In the same year she was awarded her first platinum album and the Telegatto as best new artist of 1989, with the support of votes from Italians.
In 1990 Amedeo Minghi, with his talent as a scout, sang a duet with her in Vattene amore, the song that won third place in the SanRemo Festival and has been interpreted into English 'All for the Love' by Nikka Costa. The song also won the OGAE, an international song contest, and became an evergreen, winning ten gold records. Her debut album, also entitled "Canzoni", went five times platinum and is published throughout Europe. In 1990 she again won two Telegattos: One for the song of the year and the other award for best female artist of the year.
Mietta returned to The SanRemo Festival in 1991 with Dubbi no, sung in English by Leo Sayer, and won another Telegatto as the female artist of the year. Her second album "Volano le pagine", which contains a cover version of Lover Man, won two platinum record awards.
In 1992 she released "Lasciamoci respirare" album and in 1994 "Cambia pelle", besides two duets with Riccardo Cocciante and another SanRemo with Figli di chi, song written by Nek.
In 1995 Mietta continued with musical experimentation, tackling different types of music, from soul to blues, from hip hop to the trip hop album "Daniela è felice". Her music video Oggi Dani è più felice won the MTV award in England as best foreign video transmitted for the year.
In 1996 she dubbed the voice of the beautiful, compassionate, and street-wise gypsy girl Esmeralda (both speaking and singing) in Walt Disney's 34th animated classic, "The Hunchback of Notre Dame", but was later replaced by Franca D'Amato in the less successful 2002 direct-to-video sequel. She soon appeared in Zucchero's video "Menta e rosmarino" and later debuts as an actress in "La Piovra" which was a popular Italian series. In the less successful sequel, she was replaced by Franca D'Amato.
In 1998 she was back to music with "La mia anima ", album with cover songs of popular black music. In 2000 she again took part in the SanRemo Festival with Fare l'amore, a song composed by Mango and contained in her first greatest hits "Tutto o niente."
In 2002 she got a new role for dramatic actress in the TV film Donne di mafia. Electro-pop and arabesque sounds for the 2003 album Per esempio...per amore, produced and written by Mango.
In 2004 she took a duet with Morris Albert in SanRemo Festival with Cuore and in 2005 she participated in a talent show conducted by Simona Ventura, titled Music Farm.
In 2006, after a single R&B Bugiarda, she released a pop-rock album "74100", which is the postal code of Taranto (Mietta's city). The album also featured two US songwriters: Martin Briley and Dee Kay.
In 2008 Mietta celebrated her 20th anniversary as an artist, returning for the 8th time at the Sanremo Music Festival with Baciami adesso, a song included in the album Con il sole nelle mani.
In 2011, after becoming a mother for the first time, Mietta returned to the music scene with a new album dedicated to human frailty entitled "Due soli...". The album, positioned between pop and rock, features tributes to two women: Marilyn Monroe and Sakineh Mohammadi Ashtiani. In the same year she debuted as a novelist with her first novel about women,"L'albero delle giuggiole", and narrated the audiobook "L'ultimo elfo", a fantasy written by Silvana De Mari.
In 2011 Mietta also participated as a mentor for Star Academy Italia.
In 2012 she participated in the talent show Tale e Quale Show, the Italian version of the Your Face Sounds Familiar franchise, where she does an imitation of Donna Summer, Jennifer Lopez and Maria Callas.
In 2016 Mietta returned to acting in two film: Ciao Brother and La fuga.Canzoni, 1990Volano le Pagine, 1991Lasciamoci Respirare, 1992Cambia Pelle, 1994Daniela è Felice, 1995La Mia Anima, 1998Tutto O Niente, 2000Per Esempio...Per Amore, 200374100, 2006Con il Sole nelle Mani, 2008Due soli..., 2011Lover Man of Sarah Vaughan / Billie Holiday, 1991Just the Two of Us (Dentro L'Anima) of Bill Withers / Grover Washington Jr., 1995Watch Your Step (Un Passo Falso) of Anita Baker, 1998Hot Stuff (Musica che scoppia) of Donna Summer, 1998The Tracks of My Tears (Una Strada Per Te) of Smokey Robinson and The Miracles/ Mica Paris / Aretha Franklin / Johnny Rivers, 1998We All Need Love (Angeli Noi) of Double You, 1998Body Talk (Battito) of Imagination, 1998Second Time Around (Ancora Insieme a Te) of Shalamar, 20001997 - La Piovra 8 (The Octopus), directed by Giacomo Battiato1999 - L'Ispettore Giusti, directed by Sergio Martino2001 - Donne di mafia, directed by Giuseppe Ferrara2002 - Joy - Scherzi di gioia, directed by Adriano Wajskol2016 - Ciao Brother, directed by Nicola Barnaba2016 - La fuga, directed by Stefano Calvagna1996 - Esmeralda - Disney's The Hunchback of Notre Dame (original film only)2011 - "L'ultimo elfo", written by Silvana De Mari2015 - "Come l'ortica", written by Cristina Romano2011 - "L'albero delle giuggiole"2017 - "Tra l'acqua e l'olio"