Name Michael Grunstein Fields Biochemistry | ||
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Alma mater McGill UniversityUniversity of Edinburgh Notable awards the Massry Prize from the Keck School of Medicine, University of Southern California in 2003 Similar People Charles David Allis, Roger D Kornberg, Aaron Klug, Francis Crick, Harden M McConnell | ||
Histones & Gene Expression: From "Styrofoam" to Mission Control
Michael Grunstein (born 1946 in Romania) is a Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA.
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The only surviving child of Holocaust survivors, he obtained his Bachelor of Science degree from McGill University in Montreal, and his PhD from the University of Edinburgh, Scotland. He did his post-doctoral training at Stanford University in Palo Alto, California, where he invented the colony hybridization screening technique for recombinant DNAs in David Hogness' laboratory.
Soon after coming to UCLA in 1975, Grunstein pioneered the genetic analysis of histones in yeast and showed for the first time that histones are regulators of gene activity in living cells. His studies were among the most influential to counter the prevailing belief in the 1980s that eukaryotic genes, like previously studied bacterial genes, were predominantly subjected to transcriptional activation. His laboratory's studies provided inspiration for the eukaryotic histone code and underlie the modern study of epigenetics.