Puneet Varma

Mevalonic acid

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Formula  C6H12O4
Molar mass  148.1571 g/mol
Mevalonic acid httpsuploadwikimediaorgwikipediacommonsthu

Mevalonic acid (MVA) is a key organic compound in biochemistry. The name is a contraction of dihydroxymethylvalerolactone. The carboxylate anion of mevalonic acid, which is the predominant form in biological environments is known as mevalonate, and is of major pharmaceutical importance. Drugs such as the statins (which lower levels of cholesterol) stop the production of mevalonate by inhibiting HMG-CoA reductase.

Contents

Mevalonic acid Mevalonate pathway

Chemistry

Mevalonic acid is very soluble in water and polar organic solvents. It exists in equilibrium with its lactone form, called mevalonolactone, that is formed by internal condensation of its terminal alcohol and carboxylic acid functional groups.

Biology

Mevalonic acid Mevalonic acid Wikipedia

Mevalonic acid is a precursor in the biosynthetic pathway known as the mevalonate pathway that produces terpenes and steroids. Mevalonic acid is the primary precursor of isopentenyl pyrophosphate (IPP), that is in turn the basis for all terpenoids. Mevalonic acid is chiral and the (3R)-enantiomer is the only one that is biologically active.

Mevalonic acid FileMevalonic acidpng Wikimedia Commons
Mevalonic acid Mevalonic Pathway Berbagi Ilmu
Mevalonic acid FileMevalonic acid full structurepng Wikimedia Commons

References

Mevalonic acid Wikipedia


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