Puneet Varma (Editor)

Methanobrevibacter smithii

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Higher classification

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Scientific name
Methanobrevibacter smithii

Methanobrevibacter, Archaeans, Methanobacteria, Euryarchaeota, Methanosarcina

Methanobrevibacter smithii is the predominant archaeon in the human gut. It plays an important role in the efficient digestion of polysaccharides (complex sugars) by consuming the end products of bacterial fermentation. Methanobrevibacter smithii is a single-celled microorganism from the Archaea domain. M. smithii is a methanogen, and a hydrogenotroph that recycles the hydrogen by combining it with carbon dioxide to methane. The removal of hydrogen by M. smithii is thought to allow an increase in the extraction of energy from nutrients by shifting bacterial fermentation to more oxidized end products.


Methanobrevibacter smithii Methanobrevibacter smithii Wikipedia

Importance in the human gut

Methanobrevibacter smithii Bio203 My favorite Microbe Methanobrevibacter smithii

The human gut flora consist of three main groups of hydrogen consuming microbes or hydrogenotrophs: methanogens including M. smithii; various acetogenic bacteria; and sulfate-reducing bacteria. The different roles of these microorgansims is helpful in understanding how hydrogen metabolism affects the efficiency of dietary fermentation. Accumulation of hydrogen in the gut reduces the efficiency of microbial fermentation as well as the yield of energy. Methanogenic archaea are therefore particularly significant for the human gut, because they are pivotal in the removal of excess hydrogen. M. smithii is the most common methanogenic archaeon in the human gut microbiota. Although M. smithii is paramount in digestive processes, it has a low prevalence in human feces.

Methanobrevibacter smithii Intestine archaea Methanobrevibacter smithii SEM Stock Image C032

The human gut microbiota is dominated by Bacteroidetes and Firmicutes. Archaea are most prominently represented by the methanogenic M. smithii. M. smithii is believed to be a therapeutic target for manipulation and an adaptation to the gut ecosystem.

M. smithii has significant enrichment of genes involved in the utilization of CO2, H2, and formate for methanogenesis. It also has an intact pathway to allow for CO2 utilization gene cluster for the methanogenic consumption of B. thetaiotaomicron-produced metabolite.

M. smithii supports methanogenic and nonmethanogenic removal of diverse bacterial end products of fermentation.

Methanobrevibacter smithii Project The Elizabeth H and James S McDonnell III Genome

The dominant archaeon in the human gut ecosystem affects the specificity and efficiency of bacterial digestion of dietary polysaccharides. This influences the person’s calorie harvest and body fat. Researchers have sequenced M. smithii genome, indicating that M. smithii may be a therapeutic target for reducing energy harvest in obese humans.

Cell wall and cell membrane of M. smithii compared to bacteria

Methanobrevibacter smithii cell wall and cell membrane determine susceptibility to antibiotics and statins. The cell wall (violet in the figure) is composed of pseudomurein (and not murein as in bacteria) which makes archaea resistant to lysozyme and many antibiotics that interfere with cell wall synthesis. The cell membrane (ochre in the figure) consists of a lipid bilayer or monolayer, the backbone of which is composed of isoprene units that are linked to glycerol by ether bonds. In contrast, the lipid bilayer of bacteria consists of a fatty acid backbone that is linked to glycerol by an ester bond. The presence of statin-sensitive isoprene units in the cell membrane of archaea allows Statins to selectively interfere with the growth of archaea while leaving the cell membrane of bacteria unaffected. While bacteria do not use isoprene units in their cell membrane they are still required elsewhere. These bacterial isoprene units are, however, synthesized by a pathway (MEP) that is not inhibited by statins.

In anorexic patients

In 2009, the largest human study concerning obesity and gut microbiota to date was conducted. Obesity disorders are the result of an imbalance and have serious consequences such as cardiovascular disease, type-two diabetes, and colon cancer. The gut microbiota and environment contributes to the energy imbalance because of its involvement in energy intake, conversion and storage. Culture-independent methods have shown that high proportions of methanogens can comprise up to 10% of all anaerobes in the colons of healthy adults. The quantification average of M. smithii for the anorexic group was much greater than the lean and obese group. Thus, higher amounts of M. smithii were found in anorexic patients than lean patients.

The development of Methanobrevibacter in anorexic nervosa patients may be associated with an adaptive attempt towards optimal exploitation of the low caloric diet of anorexic patients. Hence, an increase in M. smithii leads to the optimization of food transformation in low caloric diets. M. smithii could also be related to constipation, a common condition for anorexic patients.

M. smithii and constipation

Observational studies show a strong association between delayed intestinal transit and the production of methane. Experimental data suggest a direct inhibitory activity of methane on the colonic and ileal smooth muscle and a possible role for methane as a gasotransmitter. Statins can inhibit archaeal cell membrane biosynthesis apparently without affecting bacterial numbers as demonstrated in livestock and humans. This opens the possibility of a therapeutic intervention that targets a specific etiological factor of constipation while protecting the intestinal microbiome. While it is generally believed that statins inhibit methane production via their effect on cell membrane biosynthesis, mediated by inhibition of the HMGCoA reductase, there is accumulating evidence for an alternative or additional mechanism of action where statins inhibit methanogenesis directly. It appears that this other mechanism may predominate when the lactone form of statins, particularly lovastatin lactone, is administered.


Methanobrevibacter smithii Wikipedia

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