ATC code G03BB01 (WHO) CAS Number 1424-00-6 Molar mass 304.467 g/mol | Metabolism PubChem CID 15020 CAS ID 1424-00-6 | |
 | ||
AHFS/Drugs.com International Drug Names Legal status AU: S4 (Prescription only)CA: Schedule IVUS: Schedule III | ||
Mesterolone is a synthetic, orally active anabolic-androgenic steroid (AAS) and derivative of dihydrotestosterone (DHT). It is sold under the brand names Proviron (as Provironum in Asia-Pacific region) and Mestoranum, by Bayer Schering Pharma (earlier by Schering). In the late 1970s and early 1980s, it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and is rarely used for replacement therapies.
Contents
Mesterolone
Trials
In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed. In patients with dysthymia, unipolar, and bipolar depression significant improvement was observed. In this series of studies, mesterolone lead to a significant decrease in LH and testosterone levels. In another study, 100 mg mesterolone cypionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.
Bodybuilding
Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered by bodybuilders to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.