In 2001, he graduated in Political Science at the University of Szczecin. In January 2011 he received his doctorate at the Faculty of Political Science and Journalism of Adam Mickiewicz University in Poznan. His doctoral dissertation was titled "Samoobrona in Polish political party system".
In 2002 he was employed as a lecturer at the University of Szczecin. He worked there until 2005 He also lectured at the Collegium Balticum and the High School of Pedagogy in Szczecin. In 2007 he returned to work at the University of Szczecin. In 2008 he was elected a president of the "Society for Polish-Venezuelan Partnership". He also became the president of the board of Nord Media Press and worked at polish NBC. From December 2009 to December 2010 was deputy director of Polish Radio Euro. He was a lecturer at the Jan Długosz University in Czestochowa.
Piskorski was a co-founder in 2007 of the European Center of Geopolitical Analysis (Europejskie Centrum Analiz Geopolitycznych - ECAG), a pro-Eurasianism Polish thinktank dealing with issues of geopolitics. It publishes books, organizes conferences and runs portal geopolityka.org. His texts were published among others in the Polityka Narodowa, Obywatel, Myśl Polska and Myśl.pl.
As a student, Piskorski joined the Polish People's Party. He was also active in various societies promoting the idea of Pan-Slavism. He was an activist of the far right Pagan "NIKLOT" society and worked in various organizations of the popular-patriotic profile, such as the National-Democratic Party. A big impact on his political activities was the ideas of Polish political philosopher Jan Stachniuk (leader of the pre-war society "Zadruga"). Those ideas combine on the one hand passionate patriotism, and on the other consequent anti-capitalism and anti-globalism. In 2000, he travelled to Russia at the invitation of Pavel Tulaev to meet with other far right and pan-Slavic activists there. He maintains close contacts with continentalists from all over Europe who consistently argue for "de-Americanisation of the Old Continent and for the construction of Euro-continental cooperation "from Lisbon to Vladivostok".
In 2000 Piskorski quit the People's Party and in 2002 joined the Self-Defence of the Republic of Poland party to become the assistant to Member of Parliament Jan Łączny. He quit his PhD in 2005 to devote himself to politics. In 2005 he also became one of principal members of Andrzej Lepper's electoral committee during the Polish 2005 presidential election.
In the Polish 2005 parliamentary election, Piskorski successfully ran for the Sejm from the Szczecin constituency. As a deputy he was a vice-chairman of the Reprivatization Committee and worked in the Foreign Affairs Committee and the Statutory Committee. He also represented Polish Parliament in the Assembly of Western European Union. The following year he also ran for president of Szczecin in the 2006 local elections, but withdrew before the elections and supported a Law and Justice candidate instead. He failed to defend his seat in the Polish 2007 parliamentary election and failed to return to the parliament in the 2011 parliamentary election (this time running as a candidate of Polish Labour Party (Sierpień 80)).
In February 2015 Mateusz Piskorski founded a new political party called "Zmiana" ("Change"), being a political platform that combines left-wing anti-capitalist views with anti-imperialist, pacifistic social policies. At the founding meeting were invited, among many other figures, representatives of the self-proclaimed Novorossiya to inform the Polish public about their views on the War in Donbass.
In May 2016, shortly before NATO summit, Piskorski was detained by Poland's Internal Security Agency on the charges of "cooperation with Russian intelligence services, meeting intelligence officers and undertaking operational tasks from them as well as accepting payments". Sources internal to the Zmiana party have described the detention as: “an attempt to intimidate those whose views on foreign, domestic and socioeconomic policy differ from those of the government”. As of May 2017, Piskorski is still detained.
Mateusz Piskorski, as an expert and political scientist, participated and co-organized a number of election monitoring missions, since 2007 organised by the pro-Kremlin European Center of Geopolitical Analysis (ECAG):Belarusian parliamentary election, 2004
Abkhazian presidential election, 2009
Belarusian presidential election, 2010
Latvia 25 February 2011 (regional elections)
Estonian parliamentary election, 2011
Russian regional elections, 2011
Latvian parliamentary dissolution referendum, 2011
Germany 18 September 2011 (local elections)
Armenian parliamentary election, 2012
Nagorno-Karabakh presidential election, 2012
Autonomous Republic of Crimea 16 March 2014 (referendum)
Russia 12–16 September 2014 (regional elections)