Roger Dorn is now the owner of the Minnesota Twins. Aging minor league pitcher Gus Cantrell, who plays for the Fort Myers Miracle, is planning to retire. Then, Roger recruits Gus to be the manager of the Buzz, the Twins' AAA minor league affiliate. Gus's mission is to make a real team out of a bunch of players who include ballet dancer turned ballplayer Lance "The Dance" Pere, minor league lifer Frank "Pops" Morgan, Rube Baker, Taka Tanaka, Pedro Cerrano, pitcher Hog Ellis, home run hitter Billy "Downtown" Anderson, and pitcher Carlton "Doc" Windgate, a medical school graduate who throws the slowest fastball in the minors.
However, Gus clashes with Leonard Huff, the snobby manager of the Twins. One night in Minnesota, Gus and his fiancee Maggie Reynolds are having dinner with Roger and Huff at an expensive-looking restaurant, where Huff challenges Gus to a game between the Buzz and the Twins and Gus accepts the challenge.
The game is scheduled to take place at the Hubert H. Humphrey Metrodome in Minnesota. The Twins take a 3-0 lead in the 6th inning, but Downtown hits a home run that ties the game at 3-3 in the 8th inning. But in the bottom of the 9th inning, with two outs, while the Twins are up to bat, and Doc is one strike away from striking out home run hitter Carlos Liston, Huff has the stadium's lights turned off so the game can end with a tie rather than give the Buzz a chance to win in extra innings. However, the media says that the Twins were still outplayed by the Buzz.
Huff now wants to bring Downtown up to the Twins, even though Gus believes that he is not yet ready. However, Anderson jumps on the opportunity, turning his back on Gus. Without Downtown, the Buzz start losing again. With the Twins, Anderson starts hitting poorly, proving Huff wrong. Gus manages to get the Buzz back on track, and Downtown is sent back down to the Buzz, where Gus teaches him how to get more hits. Gus leads the Buzz to a division title in their league.
Gus issues a challenge for Huff to bring the Twins to Buzz Stadium for another game. If the Twins win, Gus will give his salary for the year to Huff. If Gus and the Buzz beat the Twins, Gus can take over as the manager of the Twins. Huff accepts the challenge and takes the Twins to play against the Buzz. This time, the Twins take a 4-0 lead in the 6th inning, but the Buzz still manage to come from behind with three runs, and then win the game, 5-4, thanks to a game-winning two-run home run by Downtown. Gus decides that he wants to stay with the Buzz so he can continue to work with minor league players on their skills and hopefully turn them into stars.Corbin Bernsen as Roger Dorn
Scott Bakula as Gus Cantrell
Bob Uecker as Harry Doyle
Kenny Johnson as Lance "The Dance" Pere
Thom Barry as Frank "Pops" Morgan
Eric Bruskotter as Rube Baker
Takaaki Ishibashi as Taka Tanaka
Dennis Haysbert as Pedro Cerrano
Judson Mills as Hog Ellis
Walton Goggins as Billy "Downtown" Anderson
Peter Mackenzie as Carlton "Doc" Windgate
Ted McGinley as Leonard Huff
Jensen Daggett as Maggie Reynolds
Steve Yeager as Duke Temple
Lobo Sebastian as Carlos Liston
The film earned mostly negative reviews from critics, as it currently holds a 21% rating on Rotten Tomatoes based on 19 reviews. The film failed at the box office, grossing only $3.6 million in ticket sales.
David S. Ward, the writer and producer of the original Major League, announced in 2010 that he was working on a new film, which he calls Major League 3, which instead as a proper sequel to the second film and hoped to cast the original stars Charlie Sheen, Wesley Snipes and Tom Berenger. The plot would see Sheen's character Ricky "Wild Thing" Vaughn coming out of retirement to work with a young player.