Mahoney is a surname originally designating the descandants of Mathghamhain. Notable people with the surname include:
Alexander Mahoney (1947– ), New Zealand cricketer
Andries Mahoney (1985– ), South African rugby union player
Ann Mahoney (1976–), American television, film, and stage actress
Atholstan Mahoney (1908–1979), New Zealand rugby union player
Balls Mahoney (1972–2016), American professional wrestler
Bernard Joseph Mahoney (1875–1939), Roman Catholic Bishop of Sioux Falls
Bob Mahoney (1928–2000), American Major League Baseball pitcher
Brian Mahoney (disambiguation), multiple people
Bryan Mahoney (disambiguation), multiple people
Carolyn Mahoney (1946– ), American mathematician
Charles Mahoney (1640–1679), Irish Friar Minor and Catholic martyr
Charles Mahoney (1903–1968), English artist
Chris Mahoney (disambiguation), multiple people named Chris or Christopher
Connor Mahoney (1997– ), English professional footballer
Cynthia L. Mahoney
Dan Mahoney (disambiguation), multiple people
Daniel Mahoney (disambiguation), multiple people
Dave Mahoney (1892–1947), Australian rules footballer
David Mahoney (1981– ), American soccer goalkeeper
David Mahoney (1987– ), British producer and performer
David J. Mahoney (1923–2000), American business leader, philanthropist and author
Dennis Mahony (1821–1879), American newspaper editor
Edward Joseph Mahoney (1949– ), American singer, songwriter and multi-instrumentalist
Ernestine Mahoney (1910–2000), American actress and photographer
Florence Mahoney (1929– ), Gambian Creole author
Francis Mahoney (1927–2008), American basketball player
Francis J. Mahoney (1897–1956), New York politician
Frank Mahoney (disambiguation), multiple people
George Mahoney, American Medal of Honor recipient
George E. Mahoney (1867–1955), Wisconsin politician
George P. Mahoney
Gerald Mahoney (1892–1955), Australian politician
Ike Mahoney (1901-1961), American football player
Jack Mahoney (disambiguation), multiple people
James E. Mahoney (1858–1926), American officer
James Patrick Mahoney (1927–1995), Canadian Catholic bishop
James Patrick Mahoney (New York) (1925–2002), American Catholic bishop
Janet Mahoney, English actress
Janet Claire Mahoney, (1953– ), Australian actress
Jeremiah Mahoney (1840–1902), American Medal of Honor recipient
Jerry Mahoney (disambiguation), multiple people
Jim Mahoney
Jim Mahoney (umpire)
Joan Mahoney (1943– ), American legal scholar
Joanie Mahoney (1965– ), American politician
Jock Mahoney, American actor
Joe Mahoney (1987– ), professional baseball first baseman
John Mahoney (disambiguation), multiple people
Joseph Mahoney, Welsh professional rugby league footballer
Josh Mahoney (1977– ), professional Australian rules footballer
Julie Mahoney (1978– ), Canadian fencer
Ken Mahoney (1965– ), American financial adviser
Kevin Mahoney (1965–2011), American singer
Liam Mahoney (1987– ), professional Canadian football wide receiver
Lorelei Mahoney (1984– ), American musician and actress
Loren Mahoney (1992– ), Australian association football player
Louis Mahoney
Maggie Mahoney (1922–2011), American film actress
Marie Mahoney
Mark Mahoney, American tattoo artist
Martin Mahoney (1915–1969), American justice of the peace
Mary Eliza Mahoney
Matthew Mahoney (disambiguation), multiple people
Maureen Mahoney
Megan Mahoney (1983– ), American professional basketball player
Michael Mahoney (disambiguation), several people named Michael or Mike
Neil Mahoney (1906–1973), American professional baseball scout
Patrick Mahoney
Patrick Morgan Mahoney (1929–2012), Canadian judge, politician, lawyer and businessman
Paul Mahoney (disambiguation), multiple people
Peter P. Mahoney (1848–1889), U.S. Representative from New York
Rebecca Hull (née Mahoney), (1985– ), New Zealand rugby union player
Richard Mahoney (disambiguation), multiple people
Rosemary Mahoney (1961– ), American non-fiction writer
Stephen Mahoney, American football player and coach
Steve Mahoney, Canadian politician
Suzanne Somers (née Mahoney), American actor
Thomas Mahoney (disambiguation), multiple people
Tim Mahoney (disambiguation), several people named Tim or Timothy
Tony Mahoney (1959– ), English professional football striker
Travis Mahoney (1990– ), Australian medley and backstroke swimmer
Victoria Mahoney, American filmmaker and actress
Walter J. Mahoney (1908–1982), New York politician
Will Mahoney (1894-1967), American-born vaudevillian performer and stage actor
William Mahoney (disambiguation), several people
Willis Mahoney (1895–1968), American politician
Fictional characters:
Breathless Mahoney of Dick Tracy
Carey Mahoney of Police Academy
Detective Mahoney
Mrs. Mahoney of Kim Possible