 | ||
Macbecin belongs to the ansamycin family of antibiotics and was first isolated from actinomycete bacteria. Macbecin possesses potent antitumor properties.
Contents
Structure
Macbecin has an unusual macrocyclic lactam structure. There are two variants Macbecin I and II which correspond to the oxidized 1,4-benzoquinone and reduced hydroquinone respectively.
Mechanism of action
Macbecins mechanism of action is in part due to heat shock protein Hsp90 protein inhibition.
References
Macbecin Wikipedia(Text) CC BY-SA