Species Human Entrez 4214 | Human Mouse Ensembl ENSG00000095015 | |
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Aliases MAP3K1, MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1 External IDs MGI: 1346872 HomoloGene: 8056 GeneCards: MAP3K1 | ||
Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.
Contents
Function
MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin and many growth factors.
Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.
Interactions
MAP3K1 has been shown to interact with:
References
MAP3K1 Wikipedia(Text) CC BY-SA