Species Human Entrez 4294 | Human Mouse Ensembl ENSG00000130758 | |
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Aliases MAP3K10, MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10 External IDs MGI: 1346879 HomoloGene: 1834 GeneCards: MAP3K10 | ||
Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.
Contents
Function
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Interactions
MAP3K10 has been shown to interact with:
References
MAP3K10 Wikipedia(Text) CC BY-SA