ATCvet code QV04CV01 (WHO) PubChem CID 101616 UNII D0P25S3P81 | CAS Number 90-69-7 ChemSpider 91814 | |
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AHFS/Drugs.com International Drug Names | ||
Lobeline commincations brian olsen art in action appears on fox 11 good day la
Lobeline is an alkaloid found in "Indian tobacco" (Lobelia inflata), "Devil's tobacco" (Lobelia tupa), "cardinal flower" (Lobelia cardinalis), "great lobelia" (Lobelia siphilitica), and Hippobroma longiflora. Additionally, it is also found in Lobelia chinensis. In its pure form it is a white amorphous powder which is freely soluble in water.
Contents
- Lobeline commincations brian olsen art in action appears on fox 11 good day la
- Matche commercial tylenol with lobeline
- Potential uses
- Pharmacology
- References
Matche commercial tylenol with lobeline
Potential uses
Lobeline has been sold, in tablet form, for use as a smoking cessation aid, and may have application in the treatment of other drug addictions such as addiction to amphetamines, cocaine, or alcohol.
Pharmacology
Lobeline has multiple mechanisms of action, acting as a VMAT2 ligand, which stimulates dopamine release to a moderate extent when administered alone, but reduces the dopamine release caused by methamphetamine. It also inhibits the reuptake of dopamine and serotonin, and acts as a mixed agonist–antagonist at nicotinic acetylcholine receptors to which it binds at the subunit interfaces of the extracellular domain. It is also an antagonist at μ-opioid receptors. It seems to be a P-glycoprotein inhibitor, according to at least one study. It has been hypothesized that P-glycoprotein inhibition reduces chemotherapeutic resistance in cancer, presumably affecting any substrates of P-gp.
