The name Kufra itself is a derivation from kafir, the Arabic term for non-Muslims. Kufra did not fall under the dominion of either the Arabs or the Ottomans and was colonized by the Arab Bedouin tribe of the Zuwayya only in the mid 19th century, and eventually by the Italians by the 1930s. In 1931, during the campaign of Cyrenaica, General Rodolfo Graziani easily conquered Kufra, considered a strategic region, leading about 3,000 soldiers from infantry and artillery, supported by about twenty bombers.
Kufra's location in Libya's southeast places it on the country's border with Egypt, Sudan (unlike any other Libyan district), and Chad. It borders the following regions of these countries, namely, New Valley Governorate, Egypt in the east, Shamaliyah State, Sudan in southeast, North Darfur State, Sudan in the far southeast, Bourkou-Ennedi-Tibesti Region, Chad in the south. Domestically, it borders the following districts, namely, Murzuq in west, Jufra in northwest and Al Wahat in north. Kufra is a part of Cyrenacian geographical subdivision, the largest region in Libya and which is mostly semi arid in nature. The region receives an annual rainfall of 5 in (130 mm). There are no perennial rivers in the region, but the region is abundant with groundwater aquifers. All three regions of the county have mostly a flat undulating plain and occasional plateau, with an average elevation of around 423 m (1,388 ft). Around 91 per cent of the land is covered by desert, with only 8.8 per cent agricultural land (with only 1 % arable lands) and 0.1 per cent of forests. It is desert climate in all other parts of the region. Dust storms lasting four to eight days is fairly common during Spring.
Per the census estimation of 2012, the total population in the region was 157,747 with 150,353 Libyans. The average size of the household in the country was 6.9, while the average household size of non-Libyans being 3.7. There were totally 22,713 households in the district, with 20,907 Libyan ones. The population density of the district was 1.86 persons per sq. km. Per 2006 census, there were totally 13,313 economically active people in the district. There were 6,295 government employees, 2,178 employers, 6,454 first level workers and 001 second level workers. There were 85 workers in state administration, 85 in agriculture, animal husbandry and forestry, 2,445 in agriculture & hunting, 2,029 in education, 1,558 in private enterprises, 584 in health & social work, 85 in production, 2,214 in technical work and 354 service workers. The total enrollment in schools was 17,364 and the number of people above secondary stage and less than graduation was 875. As per the report from World Health Organization (WHO), there were one communicable disease centres, one dental clinic, one general clinics, three out-patient clinics, five pharmacies, 16 PHC centres, one rural clinics and no specialized clinics.
During 2007, the northern part of Kufra District was moved to the newly created Al Wahat District. Besides the main Oasis group of the Kufra basin, four more oases belong to the region, which lie northwest of Kufra basin are Rebiana, Buzema, Wadi Zighen and Tazirbu. The oasis-valleys of Jabal Arkanu and Jebel Uweinat lie southeast of the basin. Libya became independent in 1951 from the colonial empire and generally known for its oil rich resources. As a part of decentralization in 2012, the country is administratively split into 13 regions from the original 25 municipalities, which were further divided in 1,500 communes. As of 2016, there were 22 administrative divisions in the country in the form of districts.