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James Collip

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Alma mater  University of Toronto
Known for  Insulin

Name  James Collip
Fields  Biochemistry
James Collip httpsuploadwikimediaorgwikipediacommonsthu
Born  James Bertram Collip November 20, 1892 Belleville, Ontario (1892-11-20)
Notable awards  Flavelle Medal (1936) Fellow of the Royal Society
Died  June 19, 1965, London, Canada
Education  University of Alberta, University of Toronto

Insulin frederick banting charles best james collip john mc leod

James Bertram Collip, (November 20, 1892 – June 19, 1965) was part of the Toronto group which isolated insulin. He served as the Chair of the Department of Biochemistry at McGill University from 1928–1941 and Dean of Medicine at the University of Western Ontario from 1947–1961, where he was a charter member of The Kappa Alpha Society.


James Collip httpscloudfrontualbertacamediamedicinere


James Collip James Collip Wikipedia

Born in Belleville, Ontario, he enrolled at Trinity College at the University of Toronto at the age of 15, and studied physiology and biochemistry. He obtained a Ph.D. in Biochemistry from the same university in 1916.


James Collip Insulin Discovery and Controversy Clinical Chemistry

In 1915, at the age of 22, Collip accepted a lecturing position in Edmonton in the Department of Physiology at the University of Alberta Faculty of Medicine, shortly before completing his doctorate studies. He fulfilled the role for 7 years, eventually rising to the position of Professor and Head of the Department of Biochemistry in 1922. His research at the time was mainly focused on blood chemistry of vertebrates and invertebrates.

James Collip Dr James Collip Canadian Medical Hall of Fame

He took a sabbatical leave beginning in April 1921, and travelled to Toronto on a Rockefeller Travelling Scholarship for a six-month position with Professor J. J. R. MacLeod of the University of Toronto's Department of Physiology. There his research program (on the effect of pH on the concentration of sugar in the blood) would take him to marine biological stations in Woods Hole, Massachusetts and St. Andrews, New Brunswick before he returned to Toronto late in the year.

James Collip Photograph of J B Collip in academic hood 1916 Heritage U of T

MacLeod was overseeing the work of Frederick Banting and Charles Best in their search for a treatment for diabetes which they had begun in May 1921. In December, when Banting and Best were having difficulties in refining the pancreatic extract, MacLeod freed Collip from his other research to enable him to join the research team. Collip's task was to prepare insulin in a more pure, usable form than Banting and Best had been able to achieve to date.

Success of insulin

James Collip Notable People

In January 1922, after 14-year-old Leonard Thompson suffered a severe allergic reaction to an injection of insulin, Collip achieved the goal of preparing a pancreatic extract pure enough for him to recover and to use in clinical trials. Successful trials were soon completed and the future of insulin was assured. Banting, Best and Collip subsequently shared the patent for insulin, which they sold to the University of Toronto for one dollar.

James Collip Graduation photograph of J B Collip 1912 Heritage U of T

Regrettably, due to disagreements between Banting and MacLeod, there was ill-will generated within the team. The Nobel Prize for Medicine was awarded to Banting and MacLeod in 1923. Feeling that Best had been overlooked in the award, Banting shared his portion with Best. In response, MacLeod shared his portion with Collip. Nonetheless, Collip (and Best) have been largely forgotten as co-discoverers of insulin.

Following this early success, Collip returned to Edmonton to take up a position as Head of the new Department of Biochemistry, and to pursue his own studies on hormone research. In 1928 he was recruited to McGill University in Montreal by his former graduate advisor, Archibald Macallum. Collip served as Chair of McGill's Department of Biochemistry from 1928 to 1941. From 1947-1961, Collip was appointed Dean of Medicine at the University of Western Ontario. He is regarded as a pioneer of endocrine research. He did pioneering work with the hormone Parathyroid hormone (PTH).

He died on June 19, 1965 at the age of 72.

Honours and awards

  • Fellow of the Royal Society of Canada, 1925
  • Fellow of the Royal Society, 1933
  • Honorary Doctorate D.Sc, Harvard University, 1936
  • Commander of the Order of the British Empire, 1943
  • Honorary Doctorate D.Sc, University of Oxford, 1946
  • Medal of Freedom with Silver Palm (US), 1947
  • Banting Medal of the American Diabetes Association, 1960
  • Honorary Doctorate D.Sc from the University of Western Ontario, 30 May 1964
  • References

    James Collip Wikipedia

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