Species Human Entrez 6688 | Human Mouse Ensembl ENSG00000066336 | |
Aliases SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene External IDs MGI: 98282 HomoloGene: 2346 GeneCards: SPI1 | ||
Gene music using protein sequence of spi1 spi 1 proto oncogene
Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.
Contents
Function
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development.[Citation needed] The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
Interactions
SPI1 has been shown to interact with:
References
SPI1 Wikipedia(Text) CC BY-SA