Specialty hematology ICD-9-CM 286.3, 776.3 MeSH D007020 | ICD-10 D68.2 eMedicine ped/1133 | |
Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.
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Causes
Hypoprothrombinemia can be the result of a genetic defect, may be acquired as the result of another disease process, or may be an adverse effect of medication. For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome).
It may also be a rare adverse effect to Rocephin.
Treatment
Hypoprothrombinemia can be treated with periodic infusions of purified prothrombin complexes.
- A known treatment for hypoprothrombinemia is menadoxime.
- Menatetrenone was also listed as a Antihaemorrhagic vitamin.
- 4-Amino-2-methyl-1-naphthol (Vitamin K5) is another treatment for hypoprothrombinemia.