Detective Aidan Breslin is a widower who has become emotionally distanced from his two sons, Alex and Sean. Due to his dental forensics expertise, Breslin is called to investigate a crime scene that includes human teeth and a painted message: "come and see". After matching the teeth to a missing man, Breslin investigates the murder of a woman, Mrs. Spitz, who was discovered hanging from a hook contraption in her bedroom; the same message appears on four walls. According to her autopsy report, she drowned in her own blood due to a precise stabbing. They also discover Mrs. Spitz had been pregnant, and the fetus was removed. Aidan speculates there were four attackers, who recorded the murder. After leaving the crime scene, Breslin comforts the Spitz's adopted daughter, Kristen.
The next murder shares the same M.O.; the similar hook contraption leads Breslin to a tattoo parlor whose owner constructed four devices. Another murder occurs, this time with no hooks and a message on three walls. While Breslin reviews the evidence at his home, Sean stumbles on one of the photographs. Sean's insights point Breslin to the Bible, where he discovers the killings are patterned after the Four Horsemen of the Apocalypse. Each room corresponds to a horseman; the "come and see" message is a quotation from the Book of Revelation. Kristen contacts Breslin unexpectedly, and, during their conversation, Kristen produces the missing fetus, confessing to the stunned Breslin. During her interrogation, Breslin discovers the darker side of Kristen's personality, one similar to the horseman War.
At Kristen's house, Breslin and his partner, Stingray, discover snuff videos and pictures of Kristen posing sexually with Mr. Spitz. Stingray and Breslin arrest Mr. Spitz, and his children are placed in protective custody. When Breslin confronts Kristen in jail, she claims to have been sexually abused for years and murdered Mrs. Spitz as punishment for her complicity and to hurt Mr. Spitz. Evidence discovered in the unrigged victim's stomach leads Breslin to a booby-trapped apartment. A suspects escapes, and magnesium ribbons destroy most evidence.
Meanwhile, a gay young man, Cory, has a confrontation with his brother, Taylor. After Taylor insults him, Cory hands Taylor a drugged drink. As Taylor drunkenly stumbles out to his car, a thief accosts Cory in the parking lot. Cory stabs the man, who later provides the police with Cory's description. The precision of the stab wound, and a reference to Hell leads Aidan to assume it was done by the horseman Death. Elsewhere, Taylor awakens hooked onto a rig with his eyes fixed open. Cory attempts to cut out his own heart with a bonesaw, killing himself in front of Taylor.
Breslin, convinced that there may be another victim, questions Kristen, who confirms she represents War and the unrigged victim was Famine, who betrayed their trust. She refuses to identify their leader. Breslin realizes he was meant to be assigned to the case and becomes concerned his family will be targeted next. Breslin asks Stingray to go on ahead and check his house. At the Breslin home, Stingray is attacked and knocked out. Breslin arrives later and enters Alex's room for the first time in three years. To his horror, he realizes Alex is Conquest, their leader. A clue points him to the Metropolitan Theater, where Breslin met his wife. Alex sedates him, and, when he comes to, Breslin is handcuffed to a seat as Alex dangles over the stage on the final hook rig. As Alex bleeds to death, he describes the horsemen's emotional detachment from their families. Breslin rips his handcuffs off the seating and fires his gun to detach the rigging from the ceiling. Alex awakens as his father holds him. At the Breslin home, Sean wakes up from a nightmare as Breslin comforts him. When he asks where Alex is, Breslin reassures him that Alex will be okay.Dennis Quaid as Aidan Breslin, a widower detective trying to solve the "Horsemen" case
Zhang Ziyi as Kristen Spitz; War (Red Horse)
Lou Taylor Pucci as Alex Breslin; Conquest (White Horse)
Clifton Collins, Jr. as Stingray
Patrick Fugit as Corey Kurth; Death (Pale/Green Horse)
Peter Stormare as Mr. Spitz
Daryl Dorge as Garrison Jacobs; Pestilence (Black Horse)
Eric Balfour as Taylor
Chelcie Ross as Police Chief Krupa
Liam James as Sean Breslin
Deborah Odell as Ms. Bradshaw
David Dastmalchian as Terrence
Barry Shabaka Henley as Tuck
Paul Dooley as Father Whiteleather
Shooting took place in Winnipeg, Manitoba, Canada.
Review aggregation website Rotten Tomatoes gives the film an approval rating of 33% based on six reviews; the average rating is 4.6/10. Jordan Mintzer of Variety called it a predictable film that uses four cinematic cliches: "overstylized torture, whiplash editing, compulsive script reversals and crude neon lighting".