| Oral (tablets), IV|| 5–11% (Tmax = 2 hours)|
| International Drug Names|
R03AC06 (WHO) R03CC05 (WHO)
In general: ℞ (Prescription only)
Hexoprenaline (HEX-oh-PREN-a-leen, INN) is a selective β2 adrenergic receptor agonist used in the treatment of asthma. Hexoprenaline is also used in some countries (such as Russia) as a tocolytic agent (i.e., labor suppressant), with the most common trade name being Gynipral. It is not approved by U.S. FDA.
When used as a tocolytic, hexoprenaline is contraindicated in:Hyperthyroidism
Cardiovascular diseases, e.g. cardiac arrhythmias, tachycardia, myocarditis, mitral valve disease and aortic stenosis
Ischemic heart disease
Placental abruption, vaginal bleeding and inflammatory diseases of internal genitalia (such as endometritis)
First trimester of pregnancy
It should be used with caution in people with gestational diabetes.
When concomitantly administered:Beta blockers reduce or neutralize therapeutic effects of hexoprenaline
Methylxanthines (caffeine, theobromine, theophylline) increase its action
General anaesthetics (e.g., halothane) and adrenergic receptor agonists may increase the risk of cardiovascular side effects, such as arrhythmia
Hexoprenaline is contraindicated for use with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressant (TCAs), ergot alkaloids, and dihydrotachysterol.