Girish Mahajan


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Routes of administration  Oral (tablets), IV
Bioavailability  5–11% (Tmax = 2 hours)
AHFS/  International Drug Names
ATC code  R03AC06 (WHO) R03CC05 (WHO)
Legal status  In general: ℞ (Prescription only)
Metabolism  COMT (slow O-methylation)

Hexoprenaline (HEX-oh-PREN-a-leen, INN) is a selective β2 adrenergic receptor agonist used in the treatment of asthma. Hexoprenaline is also used in some countries (such as Russia) as a tocolytic agent (i.e., labor suppressant), with the most common trade name being Gynipral. It is not approved by U.S. FDA.



When used as a tocolytic, hexoprenaline is contraindicated in:

  • Hyperthyroidism
  • Cardiovascular diseases, e.g. cardiac arrhythmias, tachycardia, myocarditis, mitral valve disease and aortic stenosis
  • Ischemic heart disease
  • Hypertension
  • Angle-closure glaucoma
  • Placental abruption, vaginal bleeding and inflammatory diseases of internal genitalia (such as endometritis)
  • Shock
  • First trimester of pregnancy
  • Breastfeeding
  • It should be used with caution in people with gestational diabetes.

    Drug-drug interactions

    When concomitantly administered:

  • Beta blockers reduce or neutralize therapeutic effects of hexoprenaline
  • Methylxanthines (caffeine, theobromine, theophylline) increase its action
  • General anaesthetics (e.g., halothane) and adrenergic receptor agonists may increase the risk of cardiovascular side effects, such as arrhythmia
  • Hexoprenaline is contraindicated for use with monoamine oxidase inhibitors (MAOIs), tricyclic antidepressant (TCAs), ergot alkaloids, and dihydrotachysterol.


    Hexoprenaline Wikipedia

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