Formula C27H44N7O20P3S | Molar mass 911.661 g/mol | |
 | ||
How drugs make sense hmg coa reductase inhibitors
HMG-CoA (or 3-hydroxy-3-methylglutaryl-coenzyme A) is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase. The researches of Minor J. Coon and Bimal Kumar Bachhawat in the 1950s at University of Illinois led to its discovery.
Contents
- How drugs make sense hmg coa reductase inhibitors
- Hmg coa
- Mevalonate pathway
- Ketogenesis pathway
- References
It is also an intermediate in the metabolism of leucine. Its immediate precursor is 3-methylglutaconyl CoA.
Hmg coa
Mevalonate pathway
HMG-CoA reductase converts it into mevalonic acid.
Ketogenesis pathway
HMG-CoA lyase breaks it into acetyl CoA and acetoacetate.
References
HMG-CoA Wikipedia(Text) CC BY-SA