Entrez 2621 | Ensembl ENSG00000183087 | |
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Aliases GAS6, AXLLG, AXSF, growth arrest specific 6 External IDs MGI: 95660 HomoloGene: 638 GeneCards: GAS6 | ||
Growth arrest-specific 6, also known as GAS6, is a human gene coding for the Gas6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.
Contents
Function
Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.
Interactions
Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3.
The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum.
References
GAS6 Wikipedia(Text) CC BY-SA