Entrez 10461 | Ensembl ENSG00000153208 | |
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Aliases MERTK, MER, RP38, c-mer, Tyro12, c-Eyk, MER proto-oncogene, tyrosine kinase External IDs MGI: 96965 HomoloGene: 4626 GeneCards: MERTK | ||
Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.
Function
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
References
MERTK Wikipedia(Text) CC BY-SA