Trisha Shetty (Editor)

Examples of in vitro transdifferentiation by lineage instructive approach

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A list of examples of transdifferentiation:

  • Mouse fibroblasts, chondroblasts, and pigmented retinal epithelial cells → myoblasts (MyoD)
  • Fibroblasts → melanocytes (MITF)
  • Glial cells → neurons (Pax6)
  • Erythorid-megakaryocytic cells → monocytic cells (SPI1/PU.1)
  • B-cell progenitors → functional macrophages (C/EBPα)
  • Rat hepatic cell line → insulin-producing cells (Pdx1 and Ngn3)
  • Fibroblasts → macrophage-like cells (PU.1 and C/EBPα or C/EBPβ)
  • Postnatal cardiac and dermal fibroblasts → cardiomyocytes (Gata4, myocyte enhancer factor 2C, and Tbx5)
  • Fibroblasts → heptaocyte-like cells (Gata4, Hnf1alpha, and Foxa3) or (Hnf4alpha and Foxa1, Foxa2 or Foxa3)
  • Fibroblasts → neurons (Ascl1, Pou3f2/Brn2, and Myt1l)
  • Human fibroblasts → neurons (Ascl1,Brn2, Mytl1, and NeuroD) or (miR-9/9-124, Neurod2, Ascl1, and Myt1l)
  • Human fibroblasts → functional neurons (miR-124, Myt1l and Brn2)
  • Fibroblasts → dopaminergic neurons (Ascl1, Brn2, Myt1l, Lmx1a, and FoxA2) or (Ascl1, Nurr1, and Lmx1a)
  • Astrocytes → dopaminergic neurons (Ascl1, Lmx1b, Nurr1)
  • References

    Examples of in vitro transdifferentiation by lineage-instructive approach Wikipedia