Trisha Shetty (Editor)

Ethoxzolamide

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ATC code
  
None

Biological half-life
  
2.5–5.5 hours

PubChem CID
  
3295

Molar mass
  
258.319 g/mol

Protein binding
  
~89%

CAS Number
  
452-35-7

IUPHAR/BPS
  
6814

CAS ID
  
452-35-7

Ethoxzolamide

Ethoxzolamide (alternatively known as ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. It is used in the treatment of glaucoma and duodenal ulcers, and as a diuretic. It may also be used in the treatment of some forms of epilepsy.

Contents

How to pronounce ethoxzolamide


Pharmacology

Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.

Mechanism of action

Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium systems.

References

Ethoxzolamide Wikipedia