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ATC code  N01AB04 (WHO)
PubChem CID  3226
DrugBank  DB00228
CAS ID  13838-16-9
CAS Number  13838-16-9
Molar mass  184.492 g/mol
Protein binding  97%
Enflurane Medicinal Chemical Structures Volatile Anesthetics Enflurane
AHFS/  Micromedex Detailed Consumer Information

Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether. Developed by Ross Terrell in 1963, it was first used clinically in 1966. It was increasingly used for inhalational anesthesia during the 1970s and 1980s but is no longer in common use.


Enflurane Enflurane Wikipedia

Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.

Side effects

Enflurane Enflurane FDA prescribing information side effects and uses

Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.

Enflurane Enflurane Wikiwand

Enflurane also lowers the threshold for seizures, and should especially not be used on people with epilepsy. Like all potent inhalation anaesthetic agents it is a known trigger of malignant hyperthermia.

Enflurane Enflurane Wikipedia

Like the other potent inhalation agents it relaxes the uterus in pregnant women which is associated with more blood loss at delivery or other procedures on the gravid uterus.

Enflurane Inhalational Anesthesia Enflurane

The obsolete (as an anaesthetic) agent methoxyflurane had a nephrotoxic effect and caused acute renal failure, usually attributed to the liberation of fluoride ions from its metabolism. Enflurane is similarly metabolised but the liberation of fluoride results in a lower plasma level and enflurane related renal failure seemed unusual if seen at all.


Enflurane Enflurane Wikiwand

The exact mechanism of the action of general anaesthetics have not been delineated. Enflurane acts as a positive allosteric modulator of the GABAA, glycine, and 5-HT3 receptors, and as a negative allosteric modulator of the AMPA, kainate, and NMDA receptors, as well as of nicotinic acetylcholine receptors.

Occupational safety

Enflurane FileEnfluranepng Wikipedia

In the workplace, people may be exposed to enflurane by breathing it in as a waste anaesthetic gas, swallowing it, eye contact, or skin contact. The National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure limit (REL) for exposure to waste anaesthetic gas of 2 ppm (15.1 mg/m3) over a 60-minute period. Symptoms of occupational exposure to enflurane include eye irritation, central nervous system depression, analgesia, anesthesia, convulsions, and respiratory depression.

Enflurane Dragerwerk Enflurane DragerVapor Vapor Anesthetic Vaporizer 191
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Enflurane Wikipedia

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