Dimethylamine dehydrogenase

In enzymology, a dimethylamine dehydrogenase (EC 1.5.8.1) is an enzyme that catalyzes the chemical reaction

dimethylamine + H₂O + electron-transferring flavoprotein ⇌ methylamine + formaldehyde + reduced electron-transferring flavoprotein

The 3 substrates of this enzyme are dimethylamine, H₂O, and electron-transferring flavoprotein, whereas its 3 products are methylamine, formaldehyde, and reduced electron-transferring flavoprotein.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a flavin as acceptor. The systematic name of this enzyme class is dimethylamine:electron-transferring flavoprotein oxidoreductase. This enzyme participates in methane metabolism. It employs one cofactor, FMN.