MedlinePlus a602007 CAS Number 308068-55-5 UNII BI6GY4U9CW | ATC code B01AB09 (WHO) ChemSpider none | |
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Danaparoid sodium (Orgaran) is an anticoagulant that works by inhibiting activated factor X (factor Xa).
Contents
Danaparoid is a heparinoid but considered to be a low molecular weight heparin by some sources. However it is chemically distinct from heparin, has different protein binding properties and thus has little cross-reactivity in heparin-intolerant patients.
It consists of a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate.
Uses
It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery.
It is also used as a heparinoid substitute in heparin-induced thrombocytopenia (HIT) which may otherwise cause paradoxical thrombosis. Danaparoid is used for thrombosis prophylaxis and treatment in heparin-induced thrombocytopenia patients, although cross-reactivity with heparin-induced antibodies can occur in 10–20% of the patients (ESRA). It has been proposed for use in Kasabach-Merritt syndrome.
Discontinuation
On August 14, 2002, this drug was withdrawn by Organon International. Due to a shortage in drug substance, the manufacturer discontinued providing the medication in the United States. It is available in several other countries.
On the Schering-Plough website, Orgaran is described as "Marketed outside the U.S."
Administration
IV and SC