ATC code B01AX04 (WHO) ChemSpider none ECHA InfoCard 100.042.305 Molar mass 475.3792 g/mol | CAS Number 24967-94-0 ChEMBL CHEMBL1909290 Formula C14H21NO15S | |
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AHFS/Drugs.com International Drug Names | ||
Medical vocabulary what does dermatan sulfate mean
Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.
Contents
- Medical vocabulary what does dermatan sulfate mean
- What is the definition of dermatan sulfate medical dictionary free online
- Function
- Pathology
- References
It is also referred to as chondroitin sulfate B, although it is no longer classified as a form of chondroitin sulfate by most sources. The formula is C14H21NO15S.
What is the definition of dermatan sulfate medical dictionary free online
Function
Dermatan sulfate may have roles in coagulation, cardiovascular disease, carcinogenesis, infection, wound repair, and fibrosis.
Pathology
Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.
An excess of dermatan sulfate in the mitral valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, mitral valve prolapse (into the left atrium) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification. Mitral valve insufficiency can lead to eccentric (volume dependent or dilated) hypertrophy and eventually left heart failure if untreated.
