Entrez 55929 | Ensembl ENSG00000178028 | |
Aliases DMAP1, DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4, DNA methyltransferase 1 associated protein 1 External IDs MGI: 1913483 HomoloGene: 41311 GeneCards: DMAP1 | ||
DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene.
Contents
Function
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Interactions
DMAP1 has been shown to interact with: