Kalpana Kalpana (Editor)

ING1

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Species
  
Human

Entrez
  
3621

Human
  
Mouse

Ensembl
  
ENSG00000153487

ING1 atlasgeneticsoncologyorgGenesImagesING1Fig3png

Aliases
  
ING1, p24ING1c, p33, p33p33ING1b, p47, p47ING1a, inhibitor of growth family member 1

External IDs
  
MGI: 1349481 HomoloGene: 40119 GeneCards: ING1

Gene music using protein sequence of ing1 inhibitor of growth family member 1


Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.

Contents

Function

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

    • Interactions

    ING1 has been shown to interact with:

    References

    ING1 Wikipedia
    (Text) CC BY-SA